Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis
نویسندگان
چکیده
منابع مشابه
Role of Fusobacteria in the serrated pathway of colorectal carcinogenesis
Fusobacteria are associated with colorectal cancer (CRC) and are amplified during colorectal carcinogenesis. Compared to the adenoma-carcinoma sequence of carcinogenesis, serrated neoplasm has distinct clinical features and a different molecular background. We aimed to compare the gut microbiome between tubular adenoma (TA) and sessile serrated adenoma/polyp (SSA/P). Patients with TA, SSA/P, or...
متن کاملSerrated Polyps and Their Alternative Pathway to the Colorectal Cancer: A Systematic Review
Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world. For a long time, only one pathway of colorectal carcinogenesis was known. In recent years, a new "alternative" pathway through serrated adenoma was described. Recent meta-analysis estimated these cancers as about 10% to 30% of all CRCs. Serrated polyps are the second most popular groups of polyps (after conventi...
متن کاملModeling the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA).
Several colorectal cancer (CRC) screening models have been developed describing the progression of adenomas to CRC. Currently, there is increasing evidence that serrated lesions can also develop into CRC. It is not clear whether screening tests have the same test characteristics for serrated lesions as for adenomas, but lower sensitivities have been suggested. Models that ignore this type of co...
متن کاملSerrated polyposis: rapid and relentless development of colorectal neoplasia.
OBJECTIVE Serrated (hyperplastic) polyposis (SP) is a rare disorder with multiple colorectal hyperplastic polyps and often sessile serrated adenomas/polyps (SSA/P) or adenomas. Although associated with colorectal cancer, the course of SP is not well described. DESIGN 44 patients with SP were studied. The results of 146 colonoscopies with median follow-up of 2.0 years (range 0-30) and a median...
متن کاملInvolvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis.
The purpose of this study is to identify colorectal serrated lesions in the inflammatory mucosa of inflammatory bowel disease (IBD), to characterize their molecular status based on BRAF and KRAS mutations, mismatch-repair (MMR) deficiency and microsatellite instability (MSI), and to verify that these molecular alterations are specific to the 'serrated neoplasia pathway' in IBD. Neoplastic lesio...
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ژورنال
عنوان ژورنال: Intestinal Research
سال: 2018
ISSN: 1598-9100,2288-1956
DOI: 10.5217/ir.2018.16.3.358